ODCs

Click node...

1 OMIM reference -
1 associated gene
5 signs/symptoms

PROTEIN INTERACTIONS: 1

1 OMIM reference -
1 associated gene
10 signs/symptoms

Lissencephaly type 1 due to doublecortin gene mutation

Hereditary cerebral hemorrhage with amyloidosis, Iowa type


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	DCX	(0.56)	APP

Citations in the biomedical literature:

Lissencephaly type 1 due to doublecortin gene mutation		Hereditary cerebral hemorrhage with amyloidosis, Iowa type
	Synonym(s): - X-linked lissencephaly type 1		Synonym(s): - HCHWA, Iowa type

	Classification (Orphanet): - Rare developmental defect during embryogenesis - Rare genetic disease - Rare neurologic disease		Classification (Orphanet): - Rare genetic disease - Rare neurologic disease - Rare systemic or rheumatologic disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): (no data available)

	Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: no data available Type of inheritance: x-linked recessive		Epidemiological data: (no data available)

	External references: 1 OMIM reference - No MeSH references		External references: 1 OMIM reference - No MeSH references

Lissencephaly type 1 due to doublecortin gene mutation		Hereditary cerebral hemorrhage with amyloidosis, Iowa type
	Very frequent - Intellectual deficit / mental / psychomotor retardation / learning disability - Seizures / epilepsy / absences / spasms / status epilepticus Frequent - Failure to thrive / difficulties for feeding in infancy / growth delay - Hypertonia / spasticity / rigidity / stiffness - Hypotonia		Very frequent - Abnormal gait - Autosomal dominant inheritance - Cerebral vascular anomalies - Feeding disorder / dysphagia / swallowing / sucking disorder / esophageal dyskinesia - Intracranial / cerebral / meningeal hemorrhage - Myoclonus / fasciculations - Psychic / behavioural troubles - Psychic / psychomotor regression / dementia / intellectual decline - Transient cerebral ischemia / stroke - Troubles of memory / amnesia / hypermnesia